Local anaesthetic medication for the treatment of asthma

Memórias do Instituto Oswaldo Cruz

Rodrigo A Siqueira¹  Jorge Cs Costa¹  Renato Sb Cordeiro¹  Magda F Serra¹  Patrícia Mr E Silva¹  Marco A Martins¹ 

[1] ,Fiocruz Instituto Oswaldo Cruz Departamento de Fisiologia e FarmacodinâmicaRio de Janeiro RJ ,Brasil

关键词: local anaesthetic;    lidocaine;    inflammation;    asthma;   

DOI  :  10.1590/S0074-02762005000900027

来源: SciELO

【 摘 要 】

It is presumed that drugs able to prevent bronchial spasm and/or inflammation may have therapeutic potential to control asthma symptoms. The local anaesthetic lidocaine has recently received increased attention as an alternative form of treatment for asthmatic patients. This paper reviews the major findings on the topic and summarizes the putative mechanisms underlying the airway effects of local anaesthetic agents. We think that lidocaine extends the spectrum of options in asthma therapy, probably by counteracting both spasmogenic and inflammatory stimuli in the bronchial airways. The possibility of development of new anti-asthma compounds based on the synthesis of lidocaine derivatives is also on the horizon.

【 授权许可】

CC BY   
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