Thymus involution in alloxan diabetes: analysis of mast cells

Memórias do Instituto Oswaldo Cruz

Eo Barreto¹  I Riederer²  Acs Arantes¹  Vf Carvalho¹  Fa Farias-filho¹  Rsb Cordeiro¹  Ma Martins¹  W Savino²  Pmr E Silva¹ 

[1] ,Fiocruz Instituto Oswaldo Cruz Departamento de Fisiologia e FarmacodinâmicaRio de Janeiro RJ ,Brasil

关键词: diabetes;    mast cells;    thymus;    extracellular matrix;   

DOI  :  10.1590/S0074-02762005000900022

来源: SciELO

【 摘 要 】

We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.

【 授权许可】

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