Mast cell changes in experimental diabetes: focus on attenuation of allergic events

Memórias do Instituto Oswaldo Cruz

Vinicius F Carvalho¹  Emiliano O Barreto¹  Renato Sb Cordeiro¹  Vincent Lagente²  Marco A Martins¹  Patrícia Mr E Silva¹ 

[1] ,Fiocruz Instituto Oswaldo Cruz Departamento de Fisiologia e FarmacodinâmicaRio de Janeiro RJ ,Brasil

关键词: diabetes;    allergy;    mast cells;    glucocorticoids;   

DOI  :  10.1590/S0074-02762005000900021

来源: SciELO

【 摘 要 】

The prevalence of atopic diseases and diabetes is increasing worldwide though the concurrence of these pathologies in individual patients is found less frequent than it would be predicted. Moreover, co-existence of diabetes and allergy is generally marked by attenuation of their respective symptoms, and effective treatment of one disease exacerbates the other. This review gives an update of the state-of-the-art concerning the intercurrence of allergy and diabetes, particularly focusing on the consequences to the allergen-evoked vascular and cellular changes. It is proposed that the reduction in mast cell numbers and reactivity may be a pivotal mechanism behind the mutual exclusion phenomenon.

【 授权许可】

CC BY   
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