Memórias do Instituto Oswaldo Cruz | |
Regulation of endothelial derived nitric oxide in health and disease | |
William C Sessa1  | |
[1] ,Yale University School of Medicine Boyer Center for Molecular MedicineNew Haven CT ,US | |
关键词: nitric oxide; endothelium; caveolin-1; heat shock protein 90; atherosclerosis; inflammation; | |
DOI : 10.1590/S0074-02762005000900004 | |
来源: SciELO | |
【 摘 要 】
Endothelial nitric oxide synthase (eNOS) is the primary physiological source of nitric oxide (NO) that regulates cardiovascular homeostasis. Historically eNOS has been thought to be a constitutively expressed enzyme regulated by calcium and calmodulin. However, in the last five years it is clear that eNOS activity and NO release can be regulated by post-translational control mechanisms (fatty acid modification and phosphorylation) and protein-protein interactions (with caveolin-1 and heat shock protein 90) that direct impinge upon the duration and magnitude of NO release. This review will summarize this information and apply the post-translational control mechanisms to disease states.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
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RO202005130046904ZK.pdf | 25KB | download |