Efficacy of Citrus reticulata and Mirazid in treatment of Schistosoma mansoni

Memórias do Instituto Oswaldo Cruz

Manal A Hamed²  Mona H Hetta¹ 

[1] ,Departments of Medicinal Chemistry

关键词: Citrus reticulata;    Mirazid;    schistosomiasis;    enzymes;    ova count;   

DOI  :  10.1590/S0074-02762005000700017

来源: SciELO

【 摘 要 】

This work has been carried out to investigate the effect of Schistosoma mansoni infection on mice livers after treatment with the ethanolic extract of Citrus reticulata root or the oleo-resin extract from Myrrh of Commiphora molmol tree (Mirazid), as a new antishistosomal drug. Marker enzymes for different cell organelles were measured; succinate dehydrogenase (SDH); lactate dehydrogenase (LDH) and its isoenzymes; glucose-6-phosphatase (G-6-Pase); acid phosphatase (AP) and 5'- nucleotidase. Liver function enzymes; aspartate aminotransferase (AST); alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were also estimated. Parasitological studies through ova count and worm burden will also be taken into consideration. The results showed a marked reduction in SDH, LDH, AST, and ALT enzyme activities and a significant increase in G-6-Pase, AP, 5'- nucleotidase, and ALP after S. mansoni infection. A noticeable alteration in LDH subunits were also noticed. Treatment with C. reticulata or Mirazid improved all the previous enzyme activities with a noticeable reduction in ova count and worm burden.

【 授权许可】

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