Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans

Memórias do Instituto Oswaldo Cruz

Edilson N Kaneshima²  Marialba A Alves De Castro-prado¹ 

[1] ,Universidade Estadual de Maringá Departamento de Análises Clínicas

关键词: benznidazole;    somatic recombination;    genotoxicity;    homozigotization index;   

DOI  :  10.1590/S0074-02762005000300020

来源: SciELO

【 摘 要 】

Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.

【 授权许可】

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