期刊论文详细信息
Memórias do Instituto Oswaldo Cruz
Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias
Rosa Magán1  Clotilde Marín1  Juan M Salas2  Mario Barrera-pérez2  Maria J Rosales1  Manuel Sánchez-moreno1 
[1] ,Universidad de Granada Instituto de Biotecnología Departamento de Parasitología
关键词: Phytomonas sp.;    triazolo-pyrimidine complexes;    chemotherapeutic agents;   
DOI  :  10.1590/S0074-02762004000600021
来源: SciELO
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【 摘 要 】

There is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops. We tested three triazolo-pyrimidine complexes [two with Pt(II), and another with Ru(III)] against promastigotes of Phytomonas sp. isolated from Euphorbia characias. The incorporation of radiolabelled precursors, ultrastructural alterations and changes in the pattern of metabolite excretion were examined. Different degrees of toxicity were found for each complex: the platinun compound showed an inhibition effect on nucleic acid synthesis, provoking alterations on the levels of mitochondria, nucleus and glycosomes. These results, together with others reported previously in our laboratory about the activity of pyrimidine derivatives, reflect the potential of these compounds as agents in the treatment of Phytomonas sp.

【 授权许可】

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 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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