Study of hantavirus infection in captive breed colonies of wild rodents

Memórias do Instituto Oswaldo Cruz

Rc Oliveira²  T Rozental²  Aa Alves-corrêa²  Ps D'andrea¹  Hg Schatzmayr²  R Cerqueira¹  Ers Lemos² 

[1] ,Fundação Oswaldo Cruz Instituto Oswaldo Cruz Departamento de Virologia

关键词: hantaviruses;    rodents;    hantavirus cardiopulmonary syndrome (HPS);   

DOI  :  10.1590/S0074-02762004000600007

来源: SciELO

【 摘 要 】

Wild sigmondontine rodents are known to be the reservoir of several serotypes of New World hantaviruses. The mechanism of viral transmission is by aerosol inhalation of the excreta from infected rodents. Considering that the captive breed colonies of various wild mammals may present a potencial risk for hantaviral transmission, we examined 85 speciemens of Thrichomys spp. (Echimyidae) and 17 speciemens of Nectomys squamipes (Sigmodontinae) from our colony for the presence of hantavirus infections. Blood samples were assayed for the presence of antibodies to Andes nucleocapsid antigen using enzyme-linked immunosorbent assay (ELISA). Additionally, serum samples from workers previously exposed to wild rodents, in the laboratories where the study was conducted, were also tested by ELISA to investigate prevalence of anti-hantavirus IgG antibodies. All blood samples were negative for hantavirus antibodies. Although these results suggest that those rodent's colonies are hantavirus free, the work emphasizes the need for hantavirus serological monitoring in wild colonized rodents and secure handling potentially infected rodents as important biosafety measures.

【 授权许可】

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