Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis

Memórias do Instituto Oswaldo Cruz

Lianet Monzote Fidalgo²  Ana Margarita Montalvo Álvarez²  Lisset Fonseca Geigel²  Rolando Pérez Pineiro¹  Margarita Suárez Navarro¹  Hortensia Rodríguez Cabrera¹ 

[1] ,Instituto de Medicina Tropical Pedro Kourí Departamento de Parasitología Ciudad de la Habana,Cuba

关键词: Leishmania;    thiadiazine;    amastigotes;   

DOI  :  10.1590/S0074-02762004000300016

来源: SciELO

【 摘 要 】

Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.

【 授权许可】

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