Antimicrobial activity in vitro of plumbagin isolated from Plumbago species

Memórias do Instituto Oswaldo Cruz

Selma Ribeiro De Paiva¹  Maria Raquel Figueiredo¹  Tânia Verônica Aragão¹  Maria Auxiliadora Coelho Kaplan² 

[1] ,UFRJ Núcleo de Pesquisas de Produtos Naturais Rio de Janeiro RJ ,Brasil

关键词: Plumbago scandens;    plumbagin;    antimicrobial activity;   

DOI  :  10.1590/S0074-02762003000700017

来源: SciELO

【 摘 要 】

Plumbagin is a naturally occurring naphthoquinone isolated from roots of Plumbago scandens. The plant was collected at the Campus of Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. P. scandens is used as a traditional medicine for the treatment of several diseases. The antimicrobial activity of plumbagin was evaluated using the macrodilution method. The compound exhibited relatively specific activity against bacteria and yeast. The minimum inhibitory concentration test showed the growth inhibiton of Staphylococcus aureus at a concentration of 1.56 µg/ml and of Candida albicans at a concentration of 0.78 µg/ml. These results suggest the naphthoquinone plumbagin as a promising antimicrobial agent.

【 授权许可】

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