Species distribution and antifungal susceptibility profile of Candida spp. bloodstream isolates from Latin American hospitals

Memórias do Instituto Oswaldo Cruz

Patrício Godoy²  Iris Nora Tiraboschi¹  Luiz Carlos Severo¹  Beatriz Bustamante¹  Belinda Calvo¹  Leila Paula De Almeida²  Daniel Archimedes Da Matta²  Arnaldo Lopes Colombo² 

[1] ,Universidade Federal de São Paulo Escola Paulista de Medicina Hospital São Paulo

关键词: candidemia;    antifungal susceptibility;    Candida spp.;   

DOI  :  10.1590/S0074-02762003000300020

来源: SciELO

【 摘 要 】

From March 1999 to March 2000, we conducted a prospective multicenter study of candidemia involving five tertiary care hospitals from four countries in Latin America. Yeast isolates were identified by classical methods and the antifungal susceptibility profile was determined according to the National Committee for Clinical Laboratory Standards microbroth assay method. During a 12 month-period we were able to collect a total of 103 bloodstream isolates of Candida spp. C. albicans was the most frequently isolated species accounting for 42% of all isolates. Non-albicans Candida species strains accounted for 58% of all episodes of candidemia and were mostly represented by C. tropicalis (24.2%) and C. parapsilosis (21.3%). It is noteworthy that we were able to identify two cases of C. lusitaniae from different institutions. In our casuistic, non-albicans Candida species isolates related to candidemic episodes were susceptible to fluconazole. Continuously surveillance programs are needed in order to identify possible changes in the species distribution and antifungal susceptibility patterns of yeasts that may occurs after increasing the use of azoles in Latin American hospitals.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License