Coexistence of antibodies to tick-borne agents of babesiosis and Lyme borreliosis in patients from Cotia county, State of São Paulo, Brazil

Memórias do Instituto Oswaldo Cruz

Natalino Hajime Yoshinari²  Milena Garcia Abrão²  Virginia Lúcia Nazário Bonoldi²  Cleber Oliveira Soares¹  Claudio Roberto Madruga¹  Alessandra Scofield¹  Carlos Luis Massard¹  Adivaldo Henrique Da Fonseca¹ 

[1],Universidade de São Paulo Faculdade de Medicina Hospital das ClínicasSão Paulo SP ,Brasil

关键词: lyme borreliosis;    lyme disease;    spirochetosis;    borreliosis;    babesiosis;    coinfection;    tick-borne disease;    Brazil;   

DOI  :  10.1590/S0074-02762003000300004

来源: SciELO

【 摘 要 】

This paper reports a case of coinfection caused by pathogens of Lyme disease and babesiosis in brothers. This was the first case of borreliosis in Brazil, acquired in Cotia County, State of São Paulo, Brazil. Both children had tick bite history, presented erythema migrans, fever, arthralgia, mialgia, and developed positive serology (ELISA and Western-blotting) directed to Borrelia burgdorferi G 39/40 and Babesia bovis antigens, mainly of IgM class antibodies, suggestive of acute disease. Also, high frequencies of antibodies to B. bovis was observed in a group of 59 Brazilian patients with Lyme borreliosis (25.4%), when compared with that obtained in a normal control group (10.2%) (chi-square = 5.6; p < 0.05). Interestingly, both children presented the highest titers for IgM antibodies directed to both infective diseases, among all patients with Lyme borreliosis.

【 授权许可】

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