High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls

Memórias do Instituto Oswaldo Cruz

Gustavo Adolfo Sierra Romero²  Érico Marlon De Moraes Flores¹  Elza Ferreira Noronha²  Vanize De Oliveira Macêdo² 

[1] ,Universidade de Brasília Núcleo de Medicina Tropical Brasília DF ,Brasil

关键词: pentavalent antimony;    heavy metals;    cutaneous leishmaniasis;    lead;    arsenic;    toxicity;   

DOI  :  10.1590/S0074-02762003000100019

来源: SciELO

【 摘 要 】

We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A.

【 授权许可】

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