Antibacterial activity of Ocimum gratissimum L.essential oil

Memórias do Instituto Oswaldo Cruz

Celso Vataru Nakamura²  Tania Ueda-nakamura²  Erika Bando²  Abrahão Fernandes Negrão Melo²  Díogenes Aparício Garcia Cortez¹  Benedito Prado Dias Filho² 

[1] ,Universidade Estadual de Maringá

关键词: Ocimum gratissimum;    essential oil;    eugenol;    antimicrobial activity;   

DOI  :  10.1590/S0074-02761999000500022

来源: SciELO

【 摘 要 】

The essential oil (EO) of Ocimum gratissimum inhibited Staphylococcus aureus at a concentration of 0.75 mg/ml. The minimal inhibitory concentrations (MICs) for Shigella flexineri, Salmonella enteritidis, Escherichia coli, Klebsiella sp., and Proteus mirabilis were at concentrations ranging from 3 to 12 mg/ml. The endpoint was not reached for Pseudomonas aeruginosa (>=24 mg/ml). The MICs of the reference drugs used in this study were similar to those presented in other reports. The minimum bactericidal concentration of EO was within a twofold dilution of the MIC for this organism. The compound that showed antibacterial activity in the EO of O. gratissimum was identified as eugenol and structural findings were further supported by gas chromatography/mass spectra retention time data. The structure was supported by spectroscopic methods.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License