The Epidemiological Impact of Antimeningococcal B Vaccination in Cuba

Memórias do Instituto Oswaldo Cruz

Antonio Pérez Rodríguez¹  Félix Dickinson¹  Alberto Baly¹  Ramón Martinez¹ 

[1] ,Instituto de Medicina Tropical 'Pedro Kourí'La Habana,Cuba

关键词: invasive meningococcal disease;    impact of vaccination;    antimeningococcal B vaccine;    vaccine effectiveness;    control of epidemic;    Cuba;   

DOI  :  10.1590/S0074-02761999000400002

来源: SciELO

【 摘 要 】

The incidence of invasive meningococcal disease (IMD) before (1984-1988) and after (1989-1994), a nationwide intervention with VA-MENGOC-BC vaccination started in 1989, was compared. The prevaccination period incidence density (ID> 8.8/ 105 year-person) was higher than the postvaccination ID (ID< 6.5/ 105 year-person). The percentage proportional differences from the start to the end of each period of ID in the vaccinal period was higher (87%) than the prevaccinal (37%) with significant differences among vaccinated groups (< 25 years old). A break-point (Chow test) was confirmed by the decrease in the ID between 1989 and 1990 in children under 1 year old, 5-9, 10-14, 15-19 and 50-54 years. Comparison of ID using maps showed a decrease in IMD in all municipalities during the postvaccination period. These findings support the epidemiological impact of VA-MENGOC-BC vaccination in the reduction of IMD morbidity.

【 授权许可】

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