Pharmacological Approaches to Antitrypanosomal Chemotherapy

Memórias do Instituto Oswaldo Cruz

Simon L Croft¹ 

[1] ,London School of Hygiene and Tropical MedicineLondon,UK

关键词: Trypanosoma brucei;    Trypanosoma cruzi;    drug delivery systems;    liposomes;    blood brain barrier;   

DOI  :  10.1590/S0074-02761999000200017

来源: SciELO

【 摘 要 】

There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and inhibitors of trypanosomatid glycosomal enzymes, trypanothione reductase, ornithine decarboxylase, S-adenosylmethionine decarboxylase, cysteine proteases and of the purine and sterol biosynthetic pathways. However, less attention has been paid to the pharmacological aspects of drug design or to the use of drug delivery systems in the chemotherapy of African trypanosomiasis and Chagas disease. A review of research on pharmacology and drug delivery systems shows that there are new opportunities for improving the chemotherapy of these diseases.

【 授权许可】

CC BY   
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