Bone marrow contribution to eosinophilic inflammation

Memórias do Instituto Oswaldo Cruz

Judah A Denburg¹  Lorna Wood¹  Gail Gauvreau¹  Roma Sehmi¹  Mark D Inman¹  Paul M O'byrne¹ 

[1] ,McMaster University Department of Medicine Hamilton Ontario ,Canada

关键词: hemopoiesis;    asthma;    inflammation;    IL-5;    eosinophils;    basophils;   

DOI  :  10.1590/S0074-02761997000800006

来源: SciELO

【 摘 要 】

Allergen-induced bone marrow responses are observable in human allergic asthmatics, involving specific increases in eosinophil-basophil progenitors (Eo/B-CFU), measured either by hemopoietic assays or by flow cytometric analyses of CD34-positive, IL-3Ralpha-positive, and/or IL-5-responsive cell populations. The results are consistent with the upregulation of an IL-5-sensitive population of progenitors in allergen-induced late phase asthmatic responses. Studies in vitro on the phenotype of developing eosinophils and basophils suggest that the early acquisition of IL-5Ralpha, as well as the capacity to produce cytokines such as GM-CSF and IL-5, are features of the differentiation process. These observations are consistent with findings in animal models, indicating that allergen-induced increases in bone marrow progenitor formation depend on hemopoietic factor(s) released post-allergen. The possibility that there is constitutive marrow upregulation of eosinophilopoiesis in allergic airways disease is also an area for future investigation.

【 授权许可】

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