Evidentiation of Paramyosin (Sm-97) as a Modulating Antigen on Granulomatous Hypersensitivity to Schistosoma mansoni Eggs

Memórias do Instituto Oswaldo Cruz

Cristine Hirsch¹  Claudia Carvalho-queiroz¹  Gloria R Franco¹  Sergio Dj Pena¹  Andrew Jg Simpson¹  Alfredo M Goes¹ 

关键词: Paramyosin;    modulation;    granuloma;    Schistosoma mansoni;   

DOI  :  10.1590/S0074-02761997000500020

来源: SciELO

【 摘 要 】

A Schistosoma mansoni adult worm anionic fraction (PIII) has previously been shown to protect mice against challenge infection and to reduce pulmonary and hepatic granulomatous hypersensitivity. Serum from PIII-immunized rabbit was used to screen a lgt11 cDNA library from S. mansoni adult worm in order to identify antigens capable of modulating granulomatous hypersensitivity. We obtained four clones with 400 (Sm-III.11), 900 (Sm-III.16), 1100 (Sm-III.10) and 1300 (Sm-III.12) bp of length. All clone-specific antibodies were able to recognize most of the PIII components. The sequence analysis showed that these clones presented high homology with S. mansoni paramyosin (Sm-97). These findings ascribe a new function to this antigen with an important role in modulation of granulomatous hypersensitivity to S. mansoni eggs

【 授权许可】

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