Immune Response to Trypanosoma cruzi Shed Acute Phase Antigen in Children from an Endemic Area for Chagas' Disease in Bolivia

Memórias do Instituto Oswaldo Cruz

Simone Frédérique Brenière¹  Nina Yaksic¹  Jenny Telleria¹  Marie-france Bosseno¹  François Noireau¹  Patrick Wincker¹  Daniel Sanchez¹ 

关键词: Trypanosoma cruzi;    shed acute;    phase antigen;    humoral response;    serological diagnosis;   

DOI  :  10.1590/S0074-02761997000400011

来源: SciELO

【 摘 要 】

A field study of the immune response to the shed acute phase antigen (SAPA) of Trypanosoma cruzi was carried out in the locality of Mizque, Cochabamba department, Bolivia. Schoolchildren (266), with an average of 8.6 ± 3.6 years, were surveyed for parasitological and serological diagnosis, as well as antibodies directed against SAPA using the corresponding recombinant protein in ELISA. The antibodies against SAPA were shown in 82% of patients presenting positive serological diagnosis (IgG specific antibodies). The positive and negative predictive values were 0.88. Antibodies anti-SAPA were shown in 80.8% of the chagasic patients in the initial stage of the infection (positive IgM serology and/or positive buffy coat (BC) test) and in 81.4% of the patients in the indeterminate stage of the infection (positive IgG serology with negative BC and IgM tests). These results show that the anti-SAPA response is not only present during the initial stage of the infection (few months) but extends some years after infection

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