Effects of Goyazensolide during in Vitro Cultivation of Schistosoma mansoni

Memórias do Instituto Oswaldo Cruz

Léo Roberto Barth¹  Ana Paula Moraes Fernandes¹  João Tadeu Ribeiro-paes¹  Vanderlei Rodrigues¹ 

关键词: Schistosoma mansoni;    schistosomiasis;    sesquiterpene lactones;    in vitro cultivation;   

DOI  :  10.1590/S0074-02761997000300022

来源: SciELO

【 摘 要 】

Goyazensolide, a component extracted of Eremanthus goyazensis showed a significant inhibitory effect on egg-laying of Schistosoma mansoni during in vitro cultivation of this parasite. Motility of the worms was also reduced under treatment with goyazensolide and 90% of mortality was reached with concentrations up to 4mg/ml. It has found that separated worms were more susceptible than worms pairing during drug exposition and female alone was significantly more susceptible than male worm in the same conditions of in vitro cultivation.Natural products isolated from plants represent potential sources for the identification of structures useful for the design of alternative molecules to be used as new drug substances against several infectious diseases

【 授权许可】

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