Repair of schistosomal intestinal vascular lesions after curative treatment

Memórias do Instituto Oswaldo Cruz

Luciana Silva¹  Zilton A. Andrade¹ 

[1] ,FIOCRUZ Centro de Pesquisas Gonçalo Moniz Laboratório de EsquitossomoseSalvador,Brasil

关键词: Schistosoma mansoni;    vascular lesions;    repair;    intestinal schistosomiasis;   

DOI  :  10.1590/S0074-02761995000300016

来源: SciELO

【 摘 要 】

The process of repairing intestinal vascular lesions induced by schistosomiasis in mice was studied before and after curative chemotherapy, by means of histopathology coupled with injections of the mesenteric veins with India ink or plastic, in this case followed by corrosion in strong acid. The granulomas were avascular, mainly formed while within blood vessels, and were associated with distortion of the intestinal vasculature in their proximity, represented by tortuosities, focal dilatation, narrowing, and anastomosis of the mucosal and submucosal veins. Two to four months after cure of schistosomiasis involuting granulomas were seen to be slowly vascularized, a process going from the periphery toward the center of the granulomas. No intravascular granulomas were seen four months after treatment. The previously distorted mucosal and submucosal veins gradually regained their normal appearance, only a slight tortuosity remaining.

【 授权许可】

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