Naturally acquired antibodies against the major merozoite surface coat protein (MSP-1) of Plasmodium falciparum acquired by residents in an endemic area of Colombia

Memórias do Instituto Oswaldo Cruz

Zillka I. Terrientes²  Kenton Kramer¹  Myriam A. Herrera¹  Sandra P. Chang¹ 

[1] ,University of Panama Faculty of Medicine Center for Research and Diagnostic of Parasite Diseases. Department of Microbiology,Panamá

关键词: Plasmodium;    immunity;    antibody;    asexual stages;   

DOI  :  10.1590/S0074-02761994000600014

来源: SciELO

【 摘 要 】

A preliminary baseline epidemiological malaria survey was conducted in the village of Punta Soldado, Colombia. Parasite prevalence and density as well as serological data were obtained from 151 asymptomatic children and adults. Fifty individuals were infected with Plasmodium falciparum. The mean parasite density was 184 parasites/mm3. Greater than 90 of the sample population were P. falciparum antibody positive as detected by the indirect immunofluorescent antibody test (IFAT). The enzyme-linked immunosorbent assay (ELISA) was used to detect antibodies against the major merozoite surface protein (MSP-1) of P. falciparum. In this population, anti-MSP-1 antibody concentration is acquired in an age dependent manner with equal immunogenicity to both the N- and C-terminal regions of the molecule. Infection at the time of sampling was associated with a higher anti-MSP-1 antibody concentration than that found in non-infected individuals. Further studies are planned to assess the role of immune and non-immune factors in limiting the number of cases of severe malaria seen in this population.

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