Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil

Memórias do Instituto Oswaldo Cruz

Loic Monjour²  Asit B. Neogy²  Ioannis Vouldoukis¹  Otamires A. Silva²  Sylvie Boisnic¹  Maria Edileuza F. Brito¹  Annette Lesot¹  Nicole Vignot¹  Jane S. Martins¹  Marcio L. Jardim¹ 

[1] ,Faculté de Médecine Pitié-Salpétrière Laboratoire de Parasitologie Paris,France

关键词: human cutaneous leishmaniasis;    Brazil;    chemotherapy;    immunotherapy;   

DOI  :  10.1590/S0074-02761994000300034

来源: SciELO

【 摘 要 】

In a complete study in 25 patients with American cutaneous leishmaniasis, caused by Leishmania braziliensis complex, immunotherapeutic efficacy of parasite derived antigen (94-67 KD) has been compared to antimonial therapy. Additionally, to delineate the mechanism of therapeutic success, microscopical features of immune response in active lesions and healed or non-healed lesions following therapy were analyzed. The results showedthat cure rates in immunotherapy and chemoterapy were equal (>83 por cento). The immunohistochemical changes in two therapeutic groups were also largely similar. The analysis of humoral and cellular immune response suggest that appropriate stimulation of T helper cells in the lesion site, in association with one or more cytokines, play a key role in the healing process.

【 授权许可】

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