Immunoregulatory mechanisms and Chagas' disease

Memórias do Instituto Oswaldo Cruz

Mireille Hontebeyrie-joskowicz¹ 

[1] ,Institut Pasteur Unité d'Immunoparasitologie Paris,France

关键词: Trypanosoma cruzi;    B cell polyclonal activation;    immunosuppression;    TH1 and TH2 subsets;    B1 (CD5 B) cells;    immunopathology;   

DOI  :  10.1590/S0074-02761992000900015

来源: SciELO

【 摘 要 】

During the course of experimental Chagas' disease, several immune disorders occur. In the acute phase, T and B cell plyclonal activation is associated to immunossupression. At the chronic stage. T cells - of the TH2 subset - participate to the pathology characteristic of Chagas'disease. Data obtained after infection of BALB/Xid mice suggest that polyclonal activation may be dependent on B1 (CD5) cell activation. Moreover, these mice fail to develop the pathological features of the chronic infection. Control of lymphokine secretion might play a key role in the clinical status of Chagas'disease.

【 授权许可】

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