Babesia divergens vaccine

Memórias do Instituto Oswaldo Cruz

A. Gorenflot²  E. Precigout¹  A. Valentin¹  G. Bissuel¹  B. Carcy²  P. Brasseur¹  Y. Moreau¹  J. Schrevel² 

[1] ,Faculté de Pharmacie Laboratoire de Biologie Cellulaire Montpellier,France

关键词: Babesia divergens;    in vitro culture;    exoatingen;    vaccine;   

DOI  :  10.1590/S0074-02761992000700047

来源: SciELO

【 摘 要 】

A vaccine strategy against Babesia divergens bovine babesiosis was sucessfully developed after perfecting of an efficient in vitro culture. Crude supernatants and purified fractions were able to induce a vaccine protection in gerbils against B. divergens infection. More, supernatants induced an effective vaccine protection in cattle. The role of B. divergens exoantigens of 17, 37, 46, 70 and 90 kDa in the development of the immune response was cleary demonstrated in gerbils, cattle, and man.

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