Dengue 2 virus enhancement in asthmatic and non asthmatic individual

Memórias do Instituto Oswaldo Cruz

Maria G. Guzman¹  Gustavo Kouri²  Maritza Soler²  Jose Bravo²  Adolfo Rodriguez De La Vega¹  Susana Vazquez²  Mayra Mune² 

[1] ,Instituto de Medicina Tropical Pedro Kouri Departamento de Virología Habana,Cuba

关键词: dengue;    macrophages;    antibody dependent;    enhancement;   

DOI  :  10.1590/S0074-02761992000400016

来源: SciELO

【 摘 要 】

During the 1981 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) Cuban epidemic, bronchial asthma (BA) was frequently found as a personal or family antecedent in dengue hemorragic fever patients. Considering that antibody dependent enhancement (ADE) plays an important role in the etiopathogenic mechanism of DHF/DSS, we decide to study the Dengue 2 virus (D2V) capability of replication in peripheral blood leukocytes (PBL) from asthmatic patients and healthy persons. In 90% of asthmatic patients and 53.8% of control group it was obtained PBL with a significant D2V enhancing activity (X² p < 0.01). Power enhancement was higher in asthmatic group. This is the first in vitro study relating BA and the dengue 2 virus immuno enhancement. The results obtained support the role of BA as a risk factor for DHF/DSS as already described on epidemiological data.

【 授权许可】

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