Dynamics of fibrosis production and resorption in intestinal schistosomiasis of mice

Memórias do Instituto Oswaldo Cruz

Rosella De Oliveira Santos²  Aryon A. Barbosa Júnior²  Zilton A. Andrade¹ 

[1] ,FIOCRUZ Centro de Pesquisas Gonçalo Moniz Salvador,Brasil

关键词: schistosomiasis;    intestinal fibrosis;    periovular granuloma;   

DOI  :  10.1590/S0074-02761992000100005

来源: SciELO

【 摘 要 】

A histological, morphometric and immunocytochemical study of schistosomal periovular granulomas in the liver and intestines of mice revealed that intestinal granulomas are smaller and contain less collagen than those in the liver. After curative treatment intestinal granulomas undergo a relatively more rapid resorption, although the general pattern of collagen degradation apparently does not differ from that observed in the liver. Tendency to form scattered, usually isolated granulomas that are only mildly fibrogenic, coupled with a well-balanced process of resorption appear as the explanation why intestinal fibrosis is not an outstanding feature of schistosomiasis as it is in the liver.

【 授权许可】

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