Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart

Memórias do Instituto Oswaldo Cruz

Maria T. Gamberini²  L. A. Skorupa¹  Caden Souccar²  Antonio J. Lapa² 

[1] ,Escola Paulista de Medicina Departamento de Farmacologia Setor de Produtos NaturaisSão Paulo,Brasil

关键词: Baccharis triptera;    gastric secretion;    medicinal plant;   

DOI  :  10.1590/S0074-02761991000600031

来源: SciELO

【 摘 要 】

Baccharus triptera Mart, is a widespread Compositae usedin Brazilian folk medicine to treat gastrointestinal disturbances, rheumatic disease, mild fever, diabetes and as an anti-helminthic. Water extract of small branches of the plant (WE) administered to mice and rats (0.1 to 2 g/Kg, p.o) did not alter spontaneous motor activity, sleeping time induced by barbiturates or the tailflick response in mice. The extract decreasedby 40 por cento the number of writhings induced by 0.8 por cento scetic acid, i.p., but did not influence paw edema induced by carrageenan or dextran in rats WE (2g/Kg, p.o.) decreased the intestinal transit of charcoal in mice by 20//. Gastric secretion in pylorus ligated rats was reduced after treatment with WE (1 and 2 g/Kg. i.p. or intraduodenal and the gastric pH was raised. The extract (1 g/Kg, p.o.) prevented gastric ulcers induced in rats by immobilization at 4ºC, but not those induced by indomethacin (10 mg/Kg, s.c.). The results indicate that WE may relieve gastrointestinal disorders by reducing acid secretion and gastrointestinal hiperactivity. Neither analgesic nor anti-inflammatory activities were detectable.

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