Toxicological and toxicogenetic effects of plants used in popular medicine and in cattle food

Memórias do Instituto Oswaldo Cruz

Lúcia R. Ribeiro²  Ana Rita P. L. Bautista¹  Ana Rita Silva²  Liana A. Sales¹  Daisy M. F. Salvadori²  Paulo C. Maia² 

[1] ,UFBA Escola de Medicina Veterinária Laboratório de Genética ToxicológicaSalvador,Brasil

关键词: chromosome aberration;    Indgofera suffruticosa;    Solanum agrarium;    poisonous plants;   

DOI  :  10.1590/S0074-02761991000600022

来源: SciELO

【 摘 要 】

Toxicological and toxicogenetic effects of aqueous (tea) and hexanica fruit extract of Indigofera suffruticosa Mill, and hydroalcoholic root extract od Solanum agrarium Stendt. Were evaluated in Balb C male mice intraperitoneally exposed. A hepatotoxic effect was observed just for animals treated with aqueous fruit extract of I. suffruticosa. In relation to the toxicogenetic effect, just the group trreated with 12.5% of toxic dose of aqueous fruit extract of I. suffruticosa showed a statistically significant increase in the frequency of cells with chromosome aberrations (cytogenetic effect), although a slight increase was also observed for the highest dose (25% of LF50_ of hydroalcoholic root extract of S. agrarium. The results obtanied show that before S. agrarium is used as medicine and before the wide use of I. suffruticosa in cattle food, careful evaluation must be done.

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