Dimensões do granuloma hepático produzido por ovos de duas linhagens geográficas do Schistosoma mansoni, no camundongo

Memórias do Instituto Oswaldo Cruz

Paulo Marcos Z. Coelho¹  Pedro Raso¹  Rômulo Teixeira De Mello¹  Nivaldo H. Toppa¹ 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Biológicas Departamento de ParasitologiaBelo Horizonte,Brasil

关键词: Schistosoma mansoni;    geographic strains;    granuloma;    Schistosoma mansoni;    cepas geográficas;    granuloma;   

DOI  :  10.1590/S0074-02761989000200009

来源: SciELO

【 摘 要 】

The authors have determined the mean diameter of granulomas in the liver of mice infected with cercariae from two different and well definite geographic strains of Schistosoma mansoni (LE, Belo Horizonte, MG, and SJ, São José dos Campos, SP). A total of 1,170 granulomas has been measured. Granulomas measured on the 60th day after infection showed larger size than the other ones measured on the 90th day. Modulation of the immunopathologic response was significantly more efficient for the LE strain, whereas the granulomas ( with 60 and 90 days) related to SJ strain were significantly larger. Data suggested a higher pathogenicity for the SJ strain. It is speculated whether these findings could explain, in part, the occurence of regional variations of the anatomo-clinical forms of schistosomiasis.

【 授权许可】

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