Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infection

Memórias do Instituto Oswaldo Cruz

Jairo Ivo Dos Santos¹  Deise Luci Campos¹  Bernardo Galvão Castro¹ 

[1] ,Instituto Oswaldo Cruz Departamento de Imunologia WHO Collaborating Centre on AIDSRio de Janeiro,Brasil

关键词: AIDS;    HIV;    serology;    Western blot;    AIDS;    HIV;    sorologia;    Western blot;   

DOI  :  10.1590/S0074-02761989000100003

来源: SciELO

【 摘 要 】

In order to investigate the IgG HIV-1 antibodies rectivity to structural components of the virus, 85 sera from infected Brazilians, comprising the total spectrum of HIV infection, were analysed by Western blot assay. The sera were confirmed as being positive to HIV with enzyme linked immuno assay (ELISA) and indirect immunofluorescence (IIF). Although the sera from patients reacted less intensively to the gag polypeptide of 55KDa, no distinctive antigen reaction patterns were observed between sera patients with different clinical forms. Because of the higher frequency of reactivity to the gag p24 in AIDS patients, the patterns of anti-HIV IgG responses are similar to those observed in their African counterparts.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License