Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability

Jornal Brasileiro de Psiquiatria

Ramiro Ronchetti²  Mariana Dal Pizzol²  Rodrigo Pestana Lopes¹  Rachel Rubin Da Silva¹  Gabriel José Chittó Gauer¹  Moisés Evandro Bauer¹ 

[1] ,Pontifícia Universidade Católica do Rio Grande do Sul Department of Psychiatry and Legal Medicine

关键词: Psychoneuroimmunology;    antidepressive agents;    lymphocytes;    cell proliferation;    Neuroimunomodulação;    antidepressivos;    linfócitos;    proliferação de células;   

DOI  :  10.1590/S0047-20852007000200007

来源: SciELO

【 摘 要 】

OBJECTIVE: Initial studies with tricyclic antidepressants demonstrated that they jeopardize the immune system activity. Recent studies suggested that selective serotonin reuptake inhibitors would have stimulating immunological effects. Here, we explored the in vitro immunological effects of two antidepressants used in clinical practice, paroxetine (selective serotonin reuptake inhibitor) and bupropion (norepinephrine and dopamine reuptake inhibitor). METHOD: Peripheral blood samples were obtained from 16 healthy volunteers and the peripheral blood mononuclear cells were isolated and cultured in vitro. We evaluated the effects of bupropion and paroxetine on cell viability as well as the ability to suppress phytohemagglutinin-induced lymphocyte proliferation. RESULTS: Both antidepressants produced neither significant effect on cell viability nor on T-cell proliferation. CONCLUSIONS: This could be of valuable information for the clinical practice when these drugs are administered. These results indicate a more favorable effect of such psychopharmacological drugs when compared to reported immunological effects associated with tryciclic antidepressants.

【 授权许可】

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