Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves

Acta Amazonica

Saulo Luis Da Silva¹  Patrícia Maria Figueiredo²  Tomomasa Yano² 

[1] ,Universidade Federal do Amazonas

关键词: Zanthoxylum;    Essential oil;    cytotoxicity;    ß-caryophyllene;    alpha-humulene;    Zanthoxylum;    Óleo Volátil;    Citotoxicidade;    beta-cariofileno;    alfa-humuleno;   

DOI  :  10.1590/S0044-59672007000200015

来源: SciELO

【 摘 要 】

Zanthoxylum rhoifolium Lam is a plant popularly used as antimicrobial, for malaria and inflammatory treatment. The essential oil of Z. rhoifolium was extracted and its cytotoxic effects against HeLa (human cervical carcinoma), A-549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), Vero (monkey kidney) cell lines and mice macrophages were evaluated. Some of the terpenes of its essential oil (ß-caryophyllene, alpha-humulene, alpha -pinene, myrcene and linalool) were also tested to verify their possible influence in the oil cytotoxic activity. The results obtained permitted to confirm that the essential oil is cytotoxic against tumoral cells (CD50 = 82.3, 90.7 and 113.6 µg/ml for A-549, HeLa e HT-29 cell lines, respectively), while it did not show cytotoxicity against non-tumoral cells (Vero and mice macrophages). Thus, the essential oil from Z. rhoifolium leaves seems to present a possible therapeuthic role due to its selective cytotoxic activity against tumoral cell lines.

【 授权许可】

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