Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Cléber De Mesquita Andrade¹  Antônia Cláudia Jácome Da Câmara¹  Daniela Ferreira Nunes¹  Paulo Marcos Da Matta Guedes¹  Wogelsanger Oliveira Pereira¹  Egler Chiari¹  Rosiane Viana Zuza Diniz¹  Lúcia Maria Da Cunha Galvão¹ 

关键词: Trypanosoma cruzi;    Chagas disease;    Chagasic cardiomyopathy;    Megaesophagus. Megacolon.;   

DOI  :  10.1590/0037-8682-0235-2015

来源: SciELO

【 摘 要 】

Abstract:INTRODUCTION : This study evaluated the clinical forms and manifestation severities of Chagas disease among serologically reactive individuals from Western Rio Grande do Norte (Northeastern Brazil).METHODS : This cross-sectional study included 186 adults who were evaluated using electrocardiography, echocardiography, chest radiography, and contrast radiography of the esophagus and colon. A clinical-epidemiological questionnaire was also used.RESULTS : The indeterminate, cardiac, digestive, and cardiodigestive clinical forms of Chagas disease were diagnosed in 51.6% (96/186), 32.2% (60/186), 8.1% (15/186) and 8.1% (15/186) of the participants, respectively. Heart failure (functional classes I-IV) was detected in 7.5% (14/186) of the participants, and 36.4% (24/66), 30.3% (20/66), 15.2% (10/66), 13.6% (9/66), and 4.5% (3/66) of the patients were at stage A, B1, B2, C, and D, respectively. Dilated cardiomyopathy and electrocardiographic changes were detected in 10.2% (19/186) and 48.1% (91/186) of the participants, respectively. Apical aneurysm was diagnosed in 10.8% (20/186) of the participants, and other changes in the segmental myocardial contractility of the left ventricle were diagnosed in 33.9% (63/186) of the participants. Megaesophagus (groups I-IV) was observed in 7% (13/186) of the participants, megacolon (grades 1-3) was detected in12.9% (24/186) of the participants, and both organs were affected in 29.2% (7/24) of the megacolon cases.CONCLUSIONS : We detected various clinical forms of Chagas disease (including the digestive form). Our findings indicate that clinical symptoms alone may not be sufficient to exclude or confirm cardiac and/or digestive damage, and the number of patients with symptomatic clinical forms may be underestimated.

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