Detection of Leishmania (Viannia) DNA in leucocytes from the blood of patients with cutaneous leishmaniasis

Revista da Sociedade Brasileira de Medicina Tropical

Carolina Cella Conter¹  Herintha Coeto Neitzke-abreu¹  Raissa Bocchi Pedroso¹  Maria Valdrinez Campana Lonardoni¹  Thaís Gomes Verzignassi Silveira¹  Sandra Mara Alessi Aristides¹ 

关键词: Polymerase chain reaction;    Leishmania ( Viannia );    Leucocyte;   

DOI  :  10.1590/0037-8682-0052-2015

来源: SciELO

【 摘 要 】

ABSTRACTINTRODUCTION:Cutaneous leishmaniasis (CL) is a serious and global public health issue, with the potential of developing a mucosal form, occurring as subclinical cases, and showing recurrence despite previous treatment.METHODS:Polymorphonuclear and mononuclear DNA obtained from 49 patients was subjected to polymerase chain reaction for detection of Leishmania (Viannia).RESULTS:DNA was detected in mononuclear cells from two patients with active primary lesions positive for CL, with infection periods of 3 and 6 months, respectively.CONCLUSIONS:The DNA of Leishmania (Viannia) indicates probable parasite dissemination possibly explaining subclinical case emergence, lesion recurrence, and mucosal lesion appearance.

【 授权许可】

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