期刊论文详细信息
Revista da Sociedade Brasileira de Medicina Tropical
Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children
Vicente Maco1  Luis Marcos1  Jaime Delgado1  Julio Herrera1  José Nestares1  Angelica Terashima1  Frine Samalvides1  Eduardo Gotuzzo1 
关键词: Fascioliasis;    Treatment;    Children;    Highlands;    Peru;   
DOI  :  10.1590/0037-8682-0148-2015
来源: SciELO
PDF
【 摘 要 】

Abstract:INTRODUCTION:The therapeutic scheme of triclabendazole (TCBZ), the recommended anthelmintic against Fasciola hepatica , involves 10mg/kg of body weight administered in a single dose; however, clinical trials in children are scarce. We evaluated the efficacy and tolerability of 2 schemes of TCBZ.METHODS: Eighty-four Peruvian children with F. hepatica eggs in their stools were allocated into 2 groups: 44 received 2 dosages of 7.5mg/kg each with a 12-h interval (Group I), and 40 received a single 10-mg/kg dose (Group II). Evaluation of efficacy was based on the presence of eggs in stools, and tolerability was based on the presence of symptoms and signs post-treatment.RESULTS: A parasitological cure was obtained in 100% of individuals from Group I and 95% of individuals from Group II. The most common adverse event was biliary colic.CONCLUSIONS: The tested scheme was efficacious and tolerable, and it might be an optimal scheme in the region. To the best of our knowledge, this represents the largest series of children treated with TCBZ in a non-hospital setting.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

【 预 览 】
附件列表
Files Size Format View
RO202005130038118ZK.pdf 2556KB PDF download
  文献评价指标  
  下载次数:5次 浏览次数:4次