Phenotypic detection of metallo-β-lactamases in Pseudomonas aeruginosa and Acinetobacter baumannii isolated from hospitalized patients in São Luis, State of Maranhão, Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Roberto Morais Luz De Carvalho¹  Sirlei Garcia Marques¹  Luis Henrique Bastos Goncalves¹  Afonso Gomes Abreu¹  Silvio Gomes Monteiro¹  Azizedite Guedes Goncalves¹ 

关键词: Metallo--lactamases;    Pseudomonas aeruginosa;    Acinetobacter baumannii;   

DOI  :  10.1590/0037-8682-1451-2013

来源: SciELO

【 摘 要 】

Introduction Acquired metallo-β-lactamases (MβL) are emerging determinants of resistance in Pseudomonas aeruginosa and Acinetobacter baumannii. The objectives of this study were to phenotypically detect MβL in imipenem-resistant P. aeruginosa and A. baumannii, to investigate the association between MβL-positive strains and hospitals, and to compare the resistance profiles of MβL-producing and non-MβL-producing strains. Methods The approximation disk and combined disk assay methods were used in this study. Results A total of 18 (38.3%) P. aeruginosa isolates and 1 (5.6%) A. baumannii isolate tested positive for the presence of MβL. Conclusions These results demonstrate the need for strict surveillance and for the adoption of preventive measures to reduce the spread of infection and potential outbreaks of disease caused by MβL-producing microorganisms.

【 授权许可】

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