Chagas disease: What is known and what should be improved: a systemic review

Revista da Sociedade Brasileira de Medicina Tropical

José Rodrigues Coura¹  José Borges-pereira¹ 

[1] ,Fundação Oswaldo Cruz Instituto Oswaldo Cruz Laboratório de Doenças ParasitáriasRio de Janeiro RJ

关键词: Chagas disesase;    Evolutive patterns;    Trypanosoma cruzi vector interactions;    New strategies for treatment;    Surveillance and control;    Doença de Chagas;    Padrão evolutivo;    Interação Trypanosoma cruzi-vetores;    Novas estratégias para o tratamento;    Vigilância e controle;   

DOI  :  10.1590/S0037-86822012000300002

来源: SciELO

【 摘 要 】

This study consists of a broad review on what is known and what should be improved regarding knowledge of Chagas disease, not only through analysis on the main studies published on the topics discussed, but to a large extent based on experience of this subject, acquired over the past 50 years (1961-2011). Among the subjects covered, we highlight the pathogenesis and evolution of infection by Trypanosoma cruzi, drugs in use and new strategies for treating Chagas disease; the serological tests for the diagnosis and the controls of cure the infection; the regional variations in prevalence, morbidity and response to treatment of the disease; the importance of metacyclogenesis of T. cruzi in different species of triatomines and its capacity to transmit Chagas infection; the risks of adaptation of wild triatomines to human dwellings; the morbidity and need for a surveillance and control program for Chagas disease in the Amazon region and the need to prioritize initiatives for controlling Chagas disease in Latin America and Mexico and in non-endemic countries, which is today a major international dilemma. Finally, we raise the need for to create a new initiative for controlling Chagas disease in the Gran Chaco, which involves parts of Argentina, Bolivia and Paraguay.

【 授权许可】

CC BY   
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