Vertical transmission of HIV-1 in the western region of the State of São Paulo

Revista da Sociedade Brasileira de Medicina Tropical

Vera Lúcia Maria Alves Gonçalves²  Charlene Troiani¹  Armênio Alcântara Ribeiro¹  Patrícia Rodrigues Naufal Spir¹  Elza Keiko Kimura Gushiken²  Renata Bonfim Vieira²  Luiz Euribel Prestes-carneiro¹ 

[1] ,Adolfo Lutz Institute Regional Laboratory of Presidente Prudente Molecular Biology SectionPresidente Prudente SP

关键词: HIV-1;    Vertical transmission;    Brazil;    HIV-1;    Transmissão vertical;    Brasil;   

DOI  :  10.1590/S0037-86822011000100002

来源: SciELO

【 摘 要 】

INTRODUCTION: This study aimed to determine the prevalence of vertical HIV-1 transmission in the western region of the State of São Paulo, Brazil. METHODS: The study analyzed the medical records of HIV-1-infected mothers and infant pairs living in the municipalities of São Paulo Regional Health Departments DRS II (Araçatuba) and DRS XI (Presidente Prudente). From March 2001 to March 2006, blood samples were collected and referred to the Molecular Biology Unit of the Adolfo Lutz Institute (ALI), Presidente Prudente. HIV-1-RNA viral load was determined by bDNA assay. RESULTS: The number of births (109/217, 50.2%) and vertical HIV-1 transmissions (6/109, 5.5%) that occurred in DRS II was similar to births (108/217, 49.8%) and vertical transmissions (7/108, 6.5%) in DRS XI (p > 0.05). Although 80% (4/5) of the infected children were male in DRS II, while in DRS XI, 75% (6/8) were female, no differences between sex regarding infected and noninfected children in the regions of Araçatuba and Presidente Prudente were verified. The overall vertical HIV-1 transmission rate was 6%. No consistent reduction in the prevalence of vertical HIV-1 transmission occurred over the years. About 20% of mothers did not know the HIV-1 status of their newborns eight months after delivery. CONCLUSIONS: In the present study, MTCT prevalence rates were about 70% higher than those previously determined in the State of São Paulo, with noreduction throughout the period.Furthermore, a significant number of mothers did not know the HIV-status of their newborns eight months after delivery.

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