Genetic characterization of rabies virus isolated from bovines and equines between 2007 and 2008, in the States of São Paulo and Minas Gerais

Revista da Sociedade Brasileira de Medicina Tropical

Carla Isabel Macedo¹  Pedro Carnieli Junior¹  Willian De Oliveira Fahl¹  Jonas Yoshitaka De Oliveira Lima¹  Rafael De Novaes Oliveira¹  Samira Maria Achkar¹  Juliana Galera Castilho¹  Maria Luiza Carrieri¹  Ivanete Kotait¹ 

[1] ,Virology Department Institute Pasteur São Paulo SP ,Brazil

关键词: Rabies virus;    Desmodus rotundus;    Genetic characterization;    Nucleoprotein gene;    Cattle;    Vírus da raiva;    Desmodus rotundus;    Caracterização genética;    Gene da nucleoproteína;    Bovinos;   

DOI  :  10.1590/S0037-86822010000200002

来源: SciELO

【 摘 要 】

INTRODUCTION: Rabies is an acute disease of the central nervous system and is responsible for the deaths of thousands of humans, wild animals and livestock, particularly cattle, as well as causing major economic losses. This study describes the genetic characterization of rabies virus variants that circulate in Desmodus rotundus populations and are transmitted to herbivores. METHODS: Fifty rabies virus isolates from bovines and equines in the States of São Paulo and Minas Gerais, Brazil, were genetically characterized and compared with sequences retrieved from GenBank. RESULTS: Two clusters (I and II) with mean nucleotide identities of 99.1 and 97.6% were found. The first of these contained nearly all the samples analyzed. Lineages from other Brazilian states grouped in cluster II. CONCLUSIONS: Analysis of the amino acid sequences of the N proteins revealed the existence of genetic markers that may indicate possible variations between geographic regions, although the biologically active regions are conserved within the species over space and time.

【 授权许可】

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