Human papillomavirus genotypes in asymptomatic young women from public schools in Rio de Janeiro, Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Ledy Horto Santos Oliveira²  Maria Diva Paes Lima Ferreira¹  Everton Faccini Augusto²  Fabiana Gil Melgaço²  Larissa Silva Santos²  Silvia Maria Baeta Cavalcanti²  Maria Luiza Garcia Rosa¹ 

[1] ,Universidade Federal Fluminense Department of Microbiology and Parasitology Niterói RJ

关键词: Human papillomavirus;    Young women;    Genotypes;    Restriction fragment length polymorphism;    Cohort study;    Papilomavírus humano;    Mulheres jovens;    Genótipos;    Polimorfismo do comprimento de fragmentos de restrição;    Estudo de corte;   

DOI  :  10.1590/S0037-86822010000100002

来源: SciELO

【 摘 要 】

INTRODUCTION: The aim of this work was to survey HPV information from a random population of young women from Rio de Janeiro, Brazil. METHODS: This cross-sectional study included cervical samples from 241 female students. To determine human papillomavirus status, polymerase chain reaction amplification was performed. HPV typing was determined by restriction fragment length polymorphism analysis. Demographic data, life style, sexual and gynecological history were obtained through use of a structured questionnaire. RESULTS: The average age of the women was 19.6 years-old (SD=3.4 years). HPV prevalence was 27.4%. Nineteen different HPV genotypes were detected, including 13 high risk types. HPV 16 was the most prevalent type (6.2%), followed by 31 (4.1 %) and 66 (3.7%). Most of the oncogenic types belonged to the A9 species (28/48). The frequency of women infected by at least one oncogenic type was significantly higher than those only infected by low risk types (18.7% versus 7.5%). Cervical changes were detected in 12.5% of the sample and were significantly linked to infection with HPV types of the A9 species. Demographic variables, sexual initiation, or number of sexual partners were not associated with HPV prevalence, variety of HPV genotypes or oncogenic types. CONCLUSIONS: The relative frequency of HPV genotypes other than vaccine types in young females should be taken into account when evaluating vaccination strategies. Due to the high prevalence of HPV infection among the population studied, implementation of sex education in schools, promotion of condom use and an organized screening program to prevent cervical cancer must be encouraged for this age group.

【 授权许可】

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