Evaluation of the histopathological hepatic lesions and opportunistic agents in Brazilian HIV patients

Revista da Sociedade Brasileira de Medicina Tropical

Graziella Hanna Pereira²  Diva Carvalho Collarile Yamagutti¹  João Silva De Mendonça¹ 

[1] ,Department of Infectious Diseases and Infection Control, Hospital BrigadeiroSão Paulo SP ,Brazil

关键词: Liver biopsy;    Mycobacteriosis;    AIDS;    Liver histology;    Biópsia hepática;    Micobacteriose;    SIDA;    Histologia hepática;   

DOI  :  10.1590/S0037-86822010000100001

来源: SciELO

【 摘 要 】

INTRODUCTION: to evaluated the type histopathological hepatic lesions and opportunistic agents in Brazilian HIV-infected patients. METHODS: we examined 52 percutaneous liver biopsies of 50 HIV-infected patients who had at least two of the following conditions: fever of unknown origin, unexplained severe emaciation, hepatomegaly or abnormal liver chemistry. The specimens were cultured for mycobacteria and fungi and stained by standard procedures. RESULTS: reactive patterns, granulomatous hepatitis and chronic active hepatitis were verified in 28 (54%), 11 (21%) and 8 (15%) of the patients respectively. Opportunistic infections were diagnosed in 18 (36%) patients: mycobacteria in 12 (24%), Cryptococcus neoformans in 5 (10%) patients and mycobacteria and yeast was isolated from the same liver fragment in one patient. CONCLUSIONS: mycobacteriosis was the most common opportunistic infection and liver tissue culture is an important method to detect opportunistic agents, even in the absence of histological lesions.

【 授权许可】

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