Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice

Revista da Sociedade Brasileira de Medicina Tropical

Valdênia Maria Oliveira Souza²  Mahasti Sahihi Macedo¹ 

[1] ,Federal University of Pernambuco Department of Pharmaceutical Sciences Laboratory of Immunopathology Keizo AsamiRecife PE ,Brazil

关键词: Ascaris suum;    Delayed-type hypersensitivity;    Immunosuppression;    IFN-γ-deficient mice;    Neutrophil;    Ascaris suum;    Hipersensibilidade tardia;    Imunossupressão;    Camundongos deficientes em IFN-γ;    Neutrófilos;   

DOI  :  10.1590/S0037-86822009000300021

来源: SciELO

【 摘 要 】

High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils.

【 授权许可】

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