Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure

Revista da Sociedade Brasileira de Medicina Tropical

Maria Imaculada Muniz-junqueira²  Lícia Maria Mota²  Rodrigo Barbosa Aires²  Luiz Fernando Junqueira Júnior¹ 

[1] ,Universidade de Brasília Faculdade de Medicina Laboratório de Imunologia CelularBrasília DF

关键词: Chagas' heart disease;    Cardiac failure;    Phagocytosis;    Nitro blue tetrazolium test;    Neutrophils;    Monocytes;    Cardiopatia chagásica;    Insuficiência cardíaca;    Fagocitose;    Teste do nitro blue tetrazolium;    Neutrófilos;    Monócitos;   

DOI  :  10.1590/S0037-86822004000600004

来源: SciELO

【 摘 要 】

We evaluated the in vitro phagocytic function and the production of microbicidal oxygen radicals by monocytes and neutrophils of 9 Chagas' heart disease subjects with heart failure and 9 without the syndrome in comparison with 11 healthy subjects, by assessing phagocytosis of Saccharomyces cerevisiae and NBT reduction by peripheral blood phagocytes. Phagocytic index of monocytes of chagasics without heart failure was significantly 6.7 and 10.6 times lower than those of controls and chagasics with the congestive syndrome, respectively, due to a lesser engagement in phagocytosis and to an inability of these cells to ingest particles. Neutrophils also show in chagasics without heart failure PI 11.2 and 19.8 times lower than that of controls and chagasics with heart failure, respectively. The percent of NBT reduction was normal and similar for the three groups. Balanced opposite effects of cardiovascular and immune disturbances may be acting in Chagas' disease subjects with heart failure paradoxically recovering the altered phagocytic function.

【 授权许可】

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