In vitro study on thiabendazole action on viability of Ascaris lumbricoides (Lineu, 1758) eggs

Revista da Sociedade Brasileira de Medicina Tropical

Cristiano Lara Massara²  Rafaela Salgado Ferreira²  Henrique Leonardo Guerra¹  Omar Dos Santos Carvalho² 

[1] ,Fundação Oswaldo Cruz Centro de Pesquisas René Rachou Laboratório de Helmintoses IntestinaisBelo Horizonte MG ,Brasil

关键词: Ascaris lumbricoides;    Thiabendazole;    Ovicide;    Ascaris lumbricoides;    Tiabendazol;    Ovicida;   

DOI  :  10.1590/S0037-86822001000400002

来源: SciELO

【 摘 要 】

The in vitro activity of thiabendazole on Ascaris lumbricoides eggs, which were recovered from uteri of worm excreted after chemotherapeutic treatment, was studied. Four concentrations of the drug were used: 1 -- 2.5 -- 5 -- and 10 ppm during 24, 48 and 72 hours of exposure. Subsequently, the eggs were centrifuged, washed three times and H2SO4 0.1N was added. The eggs were maintained in an incubator for 20 days at 28°C. Finally, the percentage of embryonated eggs was determined under a lightmicroscope at a 100X magnification. After 48 and 72 hours of thiabendazole exposure, at a concentration of 10ppm, the drug showed complete inhibition of egg embryonation.

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