Human parvovirus B19 infection in HIV-positive patients

Revista da Sociedade Brasileira de Medicina Tropical

Fábio S. Aguiar²  Daniella P. Lopes²  Anna Ricordi Bazin¹  Sérgio Setúbal¹  Bernard J. Cohen¹  Jussara P. Nascimento² 

[1] ,Universidade Federal Fluminense Departamento de Microbiologia e Parasitologia Niterói

关键词: Parvovirus B19;    AIDS;    Chronic anemia;    Opportunistic infection;    Parvovirus B19;    AIDS;    Anemia Crônica;    Infecção Oportunista;   

DOI  :  10.1590/S0037-86822001000300002

来源: SciELO

【 摘 要 】

Parvovirus B19 infects predominantly erythroid cells, leading to transient inhibition of erythropoiesis. Immunocompromised patients may be unable to produce neutralizing antibodies and may develop severe chronic anemia. Epidemiological studies done on Niterói population showed that B19 infection occurs periodically in late spring and summer. We report a study from 55 HIV infected patients attending an infectious diseases outpatient clinic in this city during a 5-month period in which B19 circulation was well documented. All patients were under anti-retroviral therapy. No anti-B19 IgM was found, but a high prevalence of IgG anti-B19 (91%) was observed. In six patients, B19 DNA was found by dot-blot hybridization techniques, but this was not confirmed by PCR. None of these 6 patients manifested anemia and only one had CD4 cell count below 200 x 10(7)/L. We conclude that persistent infection causing anemia is an infrequent finding in our HIV positive patients under drug therapy.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License