Glucantime resistant Leishmania promastigotes are sensitive to pentostam

Revista da Sociedade Brasileira de Medicina Tropical

Elizabeth Spangler Andrade Moreira¹  Juliana Becattini Guerra¹  Maria De Lourdes Petrillo-peixoto¹ 

关键词: Leishmania Pentavalent antimonial compounds;    Growth inhibition;    Experimental chemotherapy;    Leishmania;    compostos antimoniais pentavalentes;    Inibição de crescimento;    Infecção experimental;   

DOI  :  10.1590/S0037-86821992000400006

来源: SciELO

【 摘 要 】

Growth inhibition in vitro tests were used to study the susceptibility to pentostam of different Leishmania strains involved in cutaneous and mucocutaneos leishmaniasis - one glucantime sensitive strain, three naturally glucantime resistant strains and one glucantime resistant line developed by in vitro drug exposure. Contrasting with the high degree , of glucantime resistance, all strains were sensitive to pentostam. These differences suggest that there is some relationship between chemical structure and in vitro activity for these antimonial compounds. These data justify a clinical re-evaluation to compare therapeutic efficacy of glucantime and pentostam in the treatment of leishmaniasis.

【 授权许可】

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