Toxoplasma-SPECIFIC IgG SUBCLASS ANTIBODY RESPONSE IN CEREBROSPINAL FLUID SAMPLES FROM PATIENTS WITH CEREBRAL TOXOPLASMOSIS

Revista do Instituto de Medicina Tropical de São Paulo

Fernanda S. Nascimento¹  Lisandra A. Suzuki¹  Nilson Branco¹  Regina M.b. Franco¹  Paula D. Andrade¹  Sandra C.b. Costa¹  Marcelo N. Pedro¹  Cláudio L. Rossi¹ 

关键词: Cerebral toxoplasmosis;    Cerebrospinal fluid;    IgG subclasses;   

DOI  :  10.1590/S0036-46652015000500013

来源: SciELO

【 摘 要 】

SUMMARY Cerebral toxoplasmosis can be highly debilitating and occasionally fatal in persons with immune system deficiencies. In this study, we evaluated the Toxoplasma gondii-specific IgG subclass antibody response in 19 cerebrospinal fluid (CSF) samples from patients with cerebral toxoplasmosis who had a positive IgG anti-T. gondii ELISA standardized with a cyst antigen preparation. There were no significant differences between the rates of positivity and the antibody concentrations (arithmetic means of the ELISA absorbances, MEA) for IgG1 and IgG2, but the rates of positivity and MEA values for these two IgG subclasses were significantly higher than those for IgG3 and IgG4. The marked IgG2 response in CSF from patients with cerebral toxoplasmosis merits further investigation.

【 授权许可】

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