LEPROSY NEPHROPATHY: A REVIEW OF CLINICAL AND HISTOPATHOLOGICAL FEATURES

Revista do Instituto de Medicina Tropical de São Paulo

Geraldo Bezerra Da Silva Junior¹  Elizabeth De Francesco Daher¹  Roberto Da Justa Pires Neto¹  Eanes Delgado Barros Pereira¹  Gdayllon Cavalcante Meneses¹  Sônia Maria Holanda Almeida Araújo¹  Elvino José Guardão Barros¹ 

关键词: Leprosy;    Hansen disease;    Kidney dysfunction;    Chronic kidney disease;    Glomerulonephritis;   

DOI  :  10.1590/S0036-46652015000100002

来源: SciELO

【 摘 要 】

Leprosy is a chronic disease caused by Mycobacterium leprae, highly incapacitating, and with systemic involvement in some cases. Renal involvement has been reported in all forms of the disease, and it is more frequent in multibacillary forms. The clinical presentation is variable and is determined by the host immunologic system reaction to the bacilli. During the course of the disease there are the so called reactional states, in which the immune system reacts against the bacilli, exacerbating the clinical manifestations. Different renal lesions have been described in leprosy, including acute and chronic glomerulonephritis, interstitial nephritis, secondary amyloidosis and pyelonephritis. The exact mechanism that leads to glomerulonephritis in leprosy is not completely understood. Leprosy treatment includes rifampicin, dapsone and clofazimine. Prednisone and non-steroidal anti-inflammatory drugs may be used to control acute immunological episodes.

【 授权许可】

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