HTLV-1/2 seroprevalence and coinfection rate in Brazilian first-time blood donors: an 11-year follow-up

Revista do Instituto de Medicina Tropical de São Paulo

Mariana Tomazini Pinto¹  Evandra Strazza Rodrigues¹  Tathiane Maistro Malta¹  Rochele Azevedo¹  Osvaldo Massaiti Takayanagui²  Vanderléia Bárbaro Valente¹  Eugênia Maria Amorim Ubiali¹  Dimas Tadeu Covas¹  Simone Kashima¹ 

[1] ,Regional Blood Center of Ribeirão PretoRibeirão Preto SP ,Brazil

关键词: HTLV-1/2;    Blood donors;    Seroprevalence;    HTLV coinfection;   

DOI  :  10.1590/S0036-46652012000300002

来源: SciELO

【 摘 要 】

The seroprevalence and geographic distribution of HTLV-1/2 among blood donors are extremely important to transfusion services. We evaluated the seroprevalence of HTLV-1/2 infection among first-time blood donor candidates in Ribeirão Preto city and region. From January 2000 to December 2010, 1,038,489 blood donations were obtained and 301,470 were first-time blood donations. All samples were screened with serological tests for HTLV-1/2 using enzyme immunoassay (EIA). In addition, the frequency of coinfection with hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Chagas disease (CD) and syphilis was also determined. In-house PCR was used as confirmatory test for HTLV-1/2. A total of 296 (0.1%) first-time donors were serologically reactive for HTLV-1/2. Confirmatory PCR of 63 samples showed that 28 were HTLV-1 positive, 13 HTLV-2 positive, 19 negative and three indeterminate. Regarding HTLV coinfection rates, the most prevalent was with HBV (51.3%) and HCV (35.9%), but coinfection with HIV, CD and syphilis was also detected. The real number of HTLV-infected individual and coinfection rate in the population is underestimated and epidemiological studies like ours are very informative.

【 授权许可】

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